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Health effects of cannabis

However, its ability to inhibit the hepatic metabolism of other medications (such as clobazam and sodium valproate) has the potential to cause adverse effects. This is demonstrated by the increased rates of adverse events, serious adverse events and withdrawals in trials for childhood epilepsy syndromes but not other indications. Additional safety data from clinical trials outside of childhood epilepsy syndromes and from studies of OTC CBD products would be beneficial.

  • At that time, 32.6% of 12th-grade students reported ever using cannabis, 21.9% reported use in the preceding year, and 1.9% reported using on a daily basis.
  • Results of the risk of bias assessment are described in Table S3.
  • Marijuana (leaves, stems, seeds) is derived from the hemp plants Canniabis sativa or Cannabis indica.
  • The remaining 13 trials included a total of 822 participants and reported 266 different adverse outcomes, of which 33 provided sufficient data for meta-analysis (i.e., at least eight events across arms across studies per outcome) (Table 1).
  • The primary source of cannabinoid toxicity is from plant-derived cannabinoids and synthetic cannabinoids.
  • Urine drug screens are not necessary for adults as they do not change management.


It has been studied as a potential therapeutic agent for severe epilepsy. Most adolescents and adults do not warrant testing for the diagnosis or treatment of cannabis intoxication. However, if chest pain is present, it is reasonable to obtain a 12-lead electrocardiogram and possibly cardiac markers to assess myocardial ischemia or infarction. There is thought to be an elevated risk up to 4.8 times for MI within 1 hour of marijuana use. Patients with toxic ingestion should also be screened for co-ingestion, especially if electrolyte abnormalities or OTc or QRS prolongation is noted on EKG.

cannabidiol toxicity symptoms

CannaCount: an improved metric for quantifying estimates of maximum possible cannabinoid exposure

The toxicokinetics of synthetic cannabinoids are less predictable as the specifically abused compound may vary, and adulteration is not uncommon. CB2 receptors are located peripherally and are thought to affect inflammation and immune system regulation. This neurotransmitter modulation may contribute to the central and peripheral effects observed in cannabinoid toxicity. The physiological effects of synthetic cannabinoids may vary based on the specific molecule in play, as many synthetic cannabinoids are continually being produced and often contaminated with other products.

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Most people with CHS who stop using cannabis have relief from symptoms within 10 days. It has a low affinity for cannabinoid (CB) receptors, but may act as a negative allosteric modulator at the CB1 receptor [10]. His co-workers reported that he began slurring his speech and vomiting, so they called an ambulance to take him to a hospital. After assessing him, his health team administered intravenous fluids, oxygen, anti-emetics for vomiting, and consistent stimulation.

cannabidiol toxicity symptoms

Other outcomes

CBD Oil: Weighing the Risks vs. Benefits – Verywell Health

CBD Oil: Weighing the Risks vs. Benefits.

Posted: Thu, 29 Feb 2024 08:00:00 GMT [source]

Breathalyzer tests have also been proposed, but since small amounts of cannabis continue to be released from fat into the blood long after short-term impairment wears off, this method has not been promoted. However, CBD has gained popularity in recent years and is available over the counter. Depending on the cannabinoid, the route of administration will vary.

The ability to perform complex tasks may be adversely affected. Cannabinoid hyperemesis syndrome (CHS) happens when you have cycles of nausea, vomiting and abdominal pain after using cannabis (marijuana) for is cannabidiol addictive a long time. People with CHS often find temporary relief from these symptoms by taking hot baths and showers. Sedatives, called benzodiazepines, such as diazepam (Valium) or lorazepam (Ativan), may be given.

Cannabis Hyperemesis Syndrome (CHS)

  • Nearly 3 decades later, in the early 1990s, the specific cannabinoid receptors were discovered, CB1 (or Cnr1) and CB2 (or Cnr2).
  • Co-administration of CBD and valproate does not significantly alter their plasma levels or that of their metabolites [32].
  • If someone who has been using marijuana develops any of the symptoms of intoxication, has trouble breathing, or cannot be awakened, call 911 or the local emergency number.
  • They include plant-derived phytocannabinoids, synthetic cannabinoids, and endogenously-derived endocannabinoids.
  • Most people with CHS who stop using cannabis have relief from symptoms within 10 days.

Cannabinoid hyperemesis syndrome (CHS) is a very unpleasant — and potentially dangerous — complication of long-term marijuana use. Because of this possible complication, it’s important to use caution with marijuana and other cannabis products. If you think you have CHS or cannabis use disorder, talk to a healthcare provider. Marijuana is the most widely used illicit drug in Australia, most people have a pleasant experience with the psychoactive drug. Cannabinoids can have adverse effects particularly in children if high doses are consumed which result in CNS depression and a coma lasting up to 36 hours.

What is cannabinoid hyperemesis syndrome?

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